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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment selection for chronic weight reduction in addition to a reduced-calorie diet and physical activity.

Using two separate drugs to lose weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you should err to the side of caution and let the FDA do its job and demand some investigation be done so your public knows the side effects and dangers of the medications before we drive them. Keep in mind that drug companies come in business to generate income and that they would say almost anything to keep people on their medications.

Researchers found out that participants using this drug for any year, dropped a few pounds within four weeks and have kept the weight off throughout the 56 weeks in the study. Contrave is a combination from the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which might be made up of more than one active ingredient, that might make them more efficient and safer.

Combo-pilling will be the newest fad or better yet the newest in the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular could be the fact that by right now there aren't long term prescription weightloss pills that have been licensed by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in those with seizure disorders. The drug could also raise blood pressure levels and heartbeat, and shouldn't be used in individuals with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not used in patients with uncontrolled high blood pressure levels, and also by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients which has a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.


Other people who must avoid using Contrave are patients struggling with bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave should not be prescribed for women who are pregnant or trying to become pregnant.